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An AMOC shutdown scenario was simulated using the CESM1 model by performing a suite of pre-industrial ensemble runs with 1 Sv freshwater forcing in the North Atlantic. In this set, the AMOC shuts down in approximately 50 years. This ensemble run was compared with a pre-industrial control simulation where the only difference is the absence of the North Atlantic freshwater forcing so that changes between these runs are attributed to the AMOC shutdown. I found important changes for the global climate, such as the interhemispheric temperature gradient with a much cooler Northern Hemisphere, a southward shift of the Intertropical Convergence Zone, and an intensified northern Hadley Cell, all consistent with previous literature (Cheng et al., 2007; Vellinga & Wood, 2002; Zhang & Delworth, 2005). However, the experiment also revealed an acceleration of the Pacific Walker Cell and associated tropical Pacific surface cooling which is an effect not previously described in response to an AMOC shutdown. The AMOC-related Pacific cooling also has subsequent effects on global climate that give rise to an interhemispheric connection such as the Amundsen Sea Low deepening. The physical mechanisms behind the tropical Pacific changes involve an Atlantic-Pacific teleconnection. This teleconnection starts with an excess of heat in the equatorial South Atlantic due to the ceased AMOC northward heat transport and also likely related to the presence of the northern hemisphere subtropical cell as the AMOC weakens (Chang et al., 2008). This surface heat triggers convection over the equatorial South Atlantic, which in turn causes subsidence in the equatorial east Pacific and accelerates the Pacific Walker Cell. The atmosphere-ocean coupling in the tropical Pacific promotes a progressive sea surface temperature cooling due to increased upwelling and westward advection of cool waters caused by the intensification of the tradewinds from the lower branch of the Pacific Walker Cell. These findings shed light on the current understanding of the tropical response to an AMOC shutdown by using a model which, unlike many others, is capable of simulating a realistic tropical inter-basin teleconnection between the Atlantic and the Pacific oceans (Fig. 2.1 in Part I). This is in addition to having a good representation of AMOC (Danabasoglu et al., 2012) and the tropical Pacific mean state independently (Orihuela-Pinto et al., 2022b; Planton et al., 2021). These results are useful for the study of past climatic states when the AMOC was severely weakened. Hence, they contribute to the interpretation of paleoclimate evidence during periods such as the Last Glacial Maximum (Lynch-Stieglitz, 2016) and the Little Ice Age (Lund et al., 2006; Wanamaker et al., 2012). Moreover, with the projected AMOC weakening under an increased greenhouse gases scenario (Collins et al., 2013) and the possibility of a potential AMOC collapse (Bakker et al., 2016; Boers, 2021; W. Liu et al., 2017), these results are also relevant for interpreting the role of AMOC on possible future scenarios.