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Kawasaki disease Kawasaki disease causes swelling (inflammation) in children in the walls of small to medium-sized blood vessels that carry blood throughout the body. Kawasaki disease commonly leads to inflammation of the coronary arteries, which supply oxygen-rich blood to the heart. Kawasaki disease was previously called mucocutaneous lymph node syndrome because it also causes swelling in glands (lymph nodes) and mucous membranes inside the mouth, nose, eyes and throat. Children with Kawasaki disease might have high fever, swollen hands and feet with skin peeling, and red eyes and tongue. But Kawasaki disease is usually treatable, and most children recover without serious problems if they receive treatment within 10 days of onset. Symptoms To receive a diagnosis of Kawasaki disease, a child usually will have a fever greater than 102.2 F (39 C) for five or more days and at least four of the following signs and symptoms. • A rash on the main part of the body or in the genital area • An enlarged lymph node in the neck • Extremely red eyes without a thick discharge • Red, dry, cracked lips and an extremely red, swollen tongue • Swollen, red skin on the palms of the hands and the soles of the feet, with later peeling of skin on fingers and toes The symptoms might not occur at the same time, so it's important to let your child's health care provider know about a sign or symptom that has gone away. Other signs and symptoms that might develop include: • Abdominal pain • Diarrhea • Irritability • Joint pain • Vomiting Children with a high fever for five or more days who have fewer than four of the above signs and symptoms might have what's known as incomplete Kawasaki disease. Children with incomplete Kawasaki disease are still at risk of coronary artery injury and still require treatment within 10 days of the onset of symptoms. Kawasaki disease can have symptoms similar to that of multisystem inflammatory syndrome in children, which has occurred worldwide in children with COVID-19. Children with these symptoms will likely be checked for COVID-19, as well. Causes No one knows what causes Kawasaki disease, but scientists don't believe the disease is contagious from person to person. Some think that Kawasaki disease happens after a bacterial or viral infection, or that it's linked to other environmental factors. Certain genes might make children more likely to get Kawasaki disease. Risk factors Three things are known to increase a child's risk of developing Kawasaki disease. • Age. Children under 5 years old are at highest risk of Kawasaki disease. • Sex. Boys are slightly more likely than girls to develop Kawasaki disease. • Ethnicity. Children of Asian or Pacific Island descent, such as Japanese or Korean, have higher rates of Kawasaki disease. Kawasaki disease tends to occur seasonally. In North America, it usually occurs in the winter and early spring. Complications Kawasaki disease is a leading cause of acquired heart disease in children in developed countries. However, with treatment, few children have lasting damage. Heart complications include: • Inflammation of blood vessels, usually the coronary arteries, that supply blood to the heart • Inflammation of the heart muscle • Heart valve problems Any of these complications can damage the heart. Inflammation of the coronary arteries can lead to weakening and bulging of the artery wall (aneurysm). Aneurysms increase the risk of blood clots, which could lead to a heart attack or cause life-threatening internal bleeding. For a small percentage of children who develop coronary artery problems, Kawasaki disease can cause death.